Wales and Cardiff City centre back Rob Page will miss Saturday's World Cup qualifier with England at Old Trafford.
Page is out with damaged ribs, but the 30-year-old will stay with the squad to prepare for next Wednesday's home qualifier against Poland in Cardiff.
Full-back Rhys Weston is definitely out with a hamstring injury.
Andy Melville or James Collins are the candidates to partner Danny Gabbidon at the centre back, but neither of the two are regulars for their clubs sides.
Melville arrived at the team hotel on Monday having played just 20 minutes of football in seven weeks after losing his place at West Ham United.
And Collins, whose slip led to David Healy scoring Northern Ireland's second goal in last month's 2-2 draw in Cardiff, has not started a game for Cardiff since August.
Wales manager Mark Hughes could ask Mark Delaney to switch from his usual right-back role to centre back, a role he is now playing for Aston Villa.
But with Rob Edwards out injured, there are no obvious candidates to cover for Delaney.
The goalkeeping spot could also give Hughes some headaches this week after his first-choice stopper Paul Jones was dropped to the bench by Wolves on Saturday.
The only threat to Jones' place, though, would seem to come in the shape of Burnley's Danny Coyne, who has kept five clean sheets in the last six Championship games.
Wales manager Mark Hughes will have also been concerned that Jason Koumas, John Oster and Robert Earnshaw all failed to appear for their club sides over the weekend.
Hmmmmmmmmm

Page is out with damaged ribs, but the 30-year-old will stay with the squad to prepare for next Wednesday's home qualifier against Poland in Cardiff.
Full-back Rhys Weston is definitely out with a hamstring injury.
Andy Melville or James Collins are the candidates to partner Danny Gabbidon at the centre back, but neither of the two are regulars for their clubs sides.
Melville arrived at the team hotel on Monday having played just 20 minutes of football in seven weeks after losing his place at West Ham United.
And Collins, whose slip led to David Healy scoring Northern Ireland's second goal in last month's 2-2 draw in Cardiff, has not started a game for Cardiff since August.
Wales manager Mark Hughes could ask Mark Delaney to switch from his usual right-back role to centre back, a role he is now playing for Aston Villa.
But with Rob Edwards out injured, there are no obvious candidates to cover for Delaney.
The goalkeeping spot could also give Hughes some headaches this week after his first-choice stopper Paul Jones was dropped to the bench by Wolves on Saturday.
The only threat to Jones' place, though, would seem to come in the shape of Burnley's Danny Coyne, who has kept five clean sheets in the last six Championship games.
Wales manager Mark Hughes will have also been concerned that Jason Koumas, John Oster and Robert Earnshaw all failed to appear for their club sides over the weekend.
Hmmmmmmmmm
