1066familyman
Radio User
- Jan 15, 2008
- 15,185
You're not wrong!No worries. I have a high horse and find the sitting upon the saddle irresistible
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[Misc] Botox why?
- Thread starter maltaseagull
- Start date
BBassic
I changed this.
- Jul 28, 2011
- 12,337
I can sympathise with people who decide to get work done. I've got a pretty severe pectus excavatum that I've thought about getting surgically fixed. It poses little health risk and would be an entirely cosmetic decision.
If someone is unhappy with how they look and have the means and desire to change that then who are we to judge?
If someone is unhappy with how they look and have the means and desire to change that then who are we to judge?
Does it though?
Thunder Bolt
Silly old bat
Watch the Dove adverts. Women of all shapes, sizes, and skin colour are featured. They're quite uplifting.
Gabbafella
Well-known member
- Aug 22, 2012
- 4,714
My dentist has had her lips done. She used to be a very attractive woman, she now looks like a baboons arse.
dsr-burnley
Well-known member
- Aug 15, 2014
- 2,194
I'm flattered if you thought I was a doctor. Not so. I may have picked up bits and bobs of general knowledge here and there, but it's very far from comprehensive.
Does botox or other stuff have no long term effect at all? I've seen pictures of people who have had repeated procedures to try and look young, and in the end they look mummified. Or google felicity Kendall (a former devotee of fillers etc) and look at her mouth now. I'm sure the procedures have left their mark.
I dare say only one or two procedures leave little or no scar but endless repetition has is effect.
Saladpack Seagull
Just Shut Up and Paddle
My late Mum had to have Botox to relax the muscles around one of her eyes. It stopped the constant twitching which had made her very self-conscious in public, and also interfered with her sleep. It worked for about six months, then it would have to be done again. The downside for her was that after the injection her eye would stay closed for about a week before it opened up again. Bit frustrating, but it did the trick for her.
METALMICKY
Well-known member
- Jan 30, 2004
- 6,087
Such are the extent of some of the filled lips I've seen one, supposes it's a back up in case the steering wheel airbags fails to deploy
- May 8, 2018
- 9,280
My mate tried Botox once but we can’t work out if he thinks it’s shithouse or not
Does she ask you to say "Oooo oo oo, ah ah ah" nowadays?
Ha ha! Well, it was a sort of compliment.
Botulinum toxin, like some (but not all) toxins is highly selective in that it is a large complex molecule that interacts with very few human molecules. It targets cholinergic nerves (the ones that make skeletal muscle contract) leading to flaccid paralysis. The molecular mechanism involves the inactivation of SNARE protein which is essential for fusion of vesicles (storage organelles) from fusing to the membrane of the nerve terminal, meaning the neurotransmitter (acetylcholine) cannot be released when the nerve is activated by depolarization. Recovery requires resynthesis of new SNARE protein and the diffusion out of the nerve terminal of the toxin. This can take months. There is no permanent 'damage' (which is why that sweary chef needs to top up his botox to keep those brown lines at bay).
Botox is made by the bacterium clostridium bolulinum. Generalized poisoning switches off all cholinerguc transmission including 'parasynpathetic' (that manages all the body's responses that are opposite to 'fight, flight, fright'. So we get tachycardia (fast heart rate), high blood pressure and (via an effect on skeletal muscle - see above) inability to swallow and an inability to move and indeed to breath.
Normal muscle contraction is prevented locally where the toxin is injected, hence the inability of the person to make best use of their facial expressions. They may feel astonishment or anger but the emotion is not communicated to the parts of the face where the injections have been given.
Botox is 'safe' because of the way the substance is administered (locally).
I made an error if I mentioned that Irma Bunt stabbed James Bond with Botox. He got a dose of tetrodotoxin (ttx) from Jelly gish, that binds irreversibly to sodium ion channels in nerves, causing respiratory arrest as the phrenic nerve cant signal to the diaphragm. This is also reversible but it requires nerves making new sodium channels. This was why Bond was on a respirator for weeks before making a full recovery.
So in the end it is possible to make a full recovery from botox and ttx, if you can get to a respirator and intravenous feeding. For a period of weeks.
The flabby mouth is due to something entirely different - the result of lip implants not Botox) stretching the lip skin, then as the substances are absorbed or removed, your lips end up like the belly of a 30 stone man who has crash dieted to 12 stone. Loose skin, in other words. And you know what they say about loose lips. They sink ships (according to Joey Ramone, anyway)
There is no reason why you can't have repeated jabs of Botox with no ill effect.
There is no charge for this pharmacology tutorial
1066familyman
Radio User
- Jan 15, 2008
- 15,185
My mate tried Viagra once. Somehow got it in his eyes.
Did nothing for his sex life, but made him look well 'ard!
A mex eyecan
Well-known member
- Nov 3, 2011
- 3,319
deleted
maltaseagull
Well-known member
- Thread starter
- #75
Absolutely.
Gives me such a warm glow.
maltaseagull
Well-known member
- Thread starter
- #76
But despite this amazing fountain of all knowledge. You still haven't explained why they don't look in the mirror and say WTF!Ha ha! Well, it was a sort of compliment.
Botulinum toxin, like some (but not all) toxins is highly selective in that it is a large complex molecule that interacts with very few human molecules. It targets cholinergic nerves (the ones that make skeletal muscle contract) leading to flaccid paralysis. The molecular mechanism involves the inactivation of SNARE protein which is essential for fusion of vesicles (storage organelles) from fusing to the membrane of the nerve terminal, meaning the neurotransmitter (acetylcholine) cannot be released when the nerve is activated by depolarization. Recovery requires resynthesis of new SNARE protein and the diffusion out of the nerve terminal of the toxin. This can take months. There is no permanent 'damage' (which is why that sweary chef needs to top up his botox to keep those brown lines at bay).
Botox is made by the bacterium clostridium bolulinum. Generalized poisoning switches off all cholinerguc transmission including 'parasynpathetic' (that manages all the body's responses that are opposite to 'fight, flight, fright'. So we get tachycardia (fast heart rate), high blood pressure and (via an effect on skeletal muscle - see above) inability to swallow and an inability to move and indeed to breath.
Normal muscle contraction is prevented locally where the toxin is injected, hence the inability of the person to make best use of their facial expressions. They may feel astonishment or anger but the emotion is not communicated to the parts of the face where the injections have been given.
Botox is 'safe' because of the way the substance is administered (locally).
I made an error if I mentioned that Irma Bunt stabbed James Bond with Botox. He got a dose of tetrodotoxin (ttx) from Jelly gish, that binds irreversibly to sodium ion channels in nerves, causing respiratory arrest as the phrenic nerve cant signal to the diaphragm. This is also reversible but it requires nerves making new sodium channels. This was why Bond was on a respirator for weeks before making a full recovery.
So in the end it is possible to make a full recovery from botox and ttx, if you can get to a respirator and intravenous feeding. For a period of weeks.
The flabby mouth is due to something entirely different - the result of lip implants not Botox) stretching the lip skin, then as the substances are absorbed or removed, your lips end up like the belly of a 30 stone man who has crash dieted to 12 stone. Loose skin, in other words. And you know what they say about loose lips. They sink ships (according to Joey Ramone, anyway)
There is no reason why you can't have repeated jabs of Botox with no ill effect.
There is no charge for this pharmacology tutorial
Couldn't move their head.
In that case, I've yet to see it done properly.
The problem is too many people thinking this will be the answer to their insecurities, but instead of helping it just makes them look like a pig, so they do more and more until Picasso turns in his grave and the mutilated sheep falls into depression. I think it's helpful to warn people off of such treatment before it's too late.