Oh of course, hit them in the right place and you can even kill someone. It just irks me when you see the hero go "let me just take care of him", one quick smack round the chops and a 6ft henchman goes out like a candle.
Even tying them sitting up in a chair can't rouse them.
Also -
Dr Who...
Why does one punch knock people out?
Why are futuristic systems/computers/contraptions voiced by an American female who reads out specifically everything the system is doing?