If the main stream media are reporting that Spurs are applying for the postponement it will be a done deal.
There is no way that the Premier League would make a team play with the current advice of everyone remaining cautious.
A snippet from The Athletic's piece on the subject:
What about Sunday’s Premier League match against Brighton?
The situation for Premier League matches is different. For these, there is no set rule but clubs can appeal for a game to be postponed, and then it’s up to the Premier League’s board...