Why on earth would that be a problem?
It's like Leeds at home with Manchester United and Hull City also hosting fairly big ties. Not a problem as they're both 40 miles west and east. Safe enough distance.
A home tie against a struggling Championship side. Brentford have fallen apart since Dean Smith has left for Aston Villa and he'll sign most of their best players by the end of January. Could have been worse for them - I bet Newport are gutted at having to go up to Middlesbrough.